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In ancient times, vanilla was said to have aphrodisiac effects and help against fever. Although these properties remain scientifically unverified, it is known that vanilla increases levels of catecholamines, including epinephrine, more commonly known as adrenaline. In an in-vitro test, vanilla was able to block quorom quorum sensing in bacteria. In many bacteria, quorum sensing signals function as a switch for virulence in that microbes only become virulent when these signals indicate that they have the numbers to resist the host immune system response. The essential oils of vanilla and vanillin are often used in aromatherapy.